Chapter I/2: Pathological aspects of hepatic cirrhosis, multiple hepatocellular carcinoma, and umbilical metastases

 

I. Learning unit:  Hepatic cirrhosis, multiple hepatocellular carcinoma, umbilical metastasis 

Objectives and Competencies

The curriculum covers presents disorders of the liver with special emphasis on clinico-pathological implications of malignant diseases affecting the liver in multidisciplinary environment. The anatomic chapter covers he macroscopic surface and intrahepatic anatomy and lymphatic circulation of the liver. The pathology chapter describes diseases such as cirrhosis, and hepatic tumors.   The radiology chapter introduces imaging modalities used to examine morphological and functional alterations affecting the livers such as ultrasound, MR, or special techniques such as THAD or CT. The clinical chapter allows student to study general symptomatology of liver diseases, non-imaging technique of diagnosis and important aspects of the treatment of various liver diseases in an environment enriched with illustrations photos and tables. 

Chapter I/2: Pathological aspects of hepatic cirrhosis, multiple hepatocellular carcinoma, and umbilical metastases

Tibor Glasz

The chapter structure
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  • I/2.1: Main data of the presented specimen case

  • I/2.2: Description of the specimen

  • I/2.3: Hepatic cirrhosis

    • I/2.3.1: Definition

    • I/2.3.2: Morphology

    • I/2.3.3: Classification

    • I/2.3.4: Types of cirrhosis

      • I/2.3.4.1: Alcoholic cirrhosis

      • I/2.3.4.2: Viral cirrhosis

      • I/2.3.4.3: Toxic cirrhosis

      • I/2.3.4.4: Postnecrotic cirrhosis

      • I/2.3.4.5: Biliary cirrhosis

      • I/2.3.4.6: Autoimmune cirrhosis

      • I/2.3.4.7: Metabolic cirrhosis

    • I/2.3.5: Consequences and complications of cirrhosis

      • I/2.3.5.1: Signs of vascular hepatic failure

      • I/2.3.5.2: Signs of parenchymal hepatic failure

    • I/2.3.6: Numerical scoring of hepatic cirrhosis progression(i): grading based on HAI – Histological Activity Index (so-called necroinflammatory evaluation)

    • I/2.3.7: Numerical scoring of hepatic cirrhosis progression (ii): staging based on HAI – Histological Activity Index (so-called fibrosis evaluation)

  • I/2.4: Hepatic tumors

    • I/2.4.1: Classification of focal hepatic lesions

    • I/2.4.2: Hepatocellular adenoma

    • I/2.4.3: Cholangiocellular adenoma

    • I/2.4.4: Hepatocellular carcinoma (HCC)

      • I/2.4.4.1: Epidemiology, patogenesis

      • I/2.4.4.2: Morphology

    • I/2.4.5: Cholangiocellular carcinoma (CCC)

    • I/2.4.6: Hepatoblastoma

    • I/2.4.7: Hemangioma

    • I/2.4.8: Hemangiosarcoma/hemangioendothelioma

    • I/2.4.9: Secondary (metastatic) hepatic tumors

    • I/2.4.10: Tumor-like lesions

    • I/2.4.11: The molecular pathological background of liver cancer (hepatocellular carcinoma)

    • I/2.4.12: The molecular pathological background of gall bladder and bile duct cancers (cholangiocellular carcinoma)

    • I/2.4.13: Gene silencing (promoter methylation) in hepato- and cholangiocellular carcinoma

    • I/2.4.14: Targeted therapy

References
irodalom

Schaff Zs, Illyés Gy: A máj és az epeutak patológiája. In: Patológia. Szerk.: Kopper L, Schaff Zs. Medicina, Budapest 2004; ISBN 963 242 920 6; pp. 821-874.

Desmet VJ, Rosai J: Liver. In: Rosai and Ackerman’s Surgical Pathology. Szerk.: Rosai J. Mosby 2004; ISBN 032 301 342 2; pp. 917-1033.

Kopper L, Tímár J: Molekuláris onkológia. Semmelweis Kiadó, Budapest 2007; ISBN 978 963 9656 79 6.

Kopper L, Tímár J, Becságh P, Nagy Zs: Célzott diagnosztika és célzott terápia az onkológiában 2. Semmelweis Kiadó, Budapest 2011; ISBN 978 963 331 199 8.
Last modified: Monday, 28 April 2014, 3:01 PM