III. Learning unit: Large gastrointestinal stromal tumor (GIST) in the stomach

Objectives and Competencies

The curriculum covers clinico-pathological implications of GIST in multidisciplinary environment. The anatomic chapter describes functional anatomy of the stomach, blood supply, innervation, the histology of the gastric wall. The pathology chapter describes frequent location of GIST, appearance, macroscopic and microscopic features, immune reactivity, molecular genetic background, the main groups of the disease, evaluation difficulties of tumor dignity. Radiologic chapter introduces imaging modalities used to diagnose GIST as well as radiological appearance of GIST on ultrasound, CT, MRI, PET, and angiography as well as imaging modalities used to evaluate treatment efficacy morphological alterations of diverticulosis, such as X-ray, ultrasound and CT. The clinical chapter allows student to study epidemiology, clinical course, symptomatology, diagnosis, differential diagnosis and treatment option in an environment enriched with illustrations photos and tables. 

III./1.: Anatomical background – the stomach (gaster)

Altdorfer Károly

The chapter structure

• III./1.1.: Descriptive and functional anatomy of the stomach

  • III./1.1.1.: Introduction

  • III./1.1.2.: Gross anatomy

  • III./1.1.3.: The motility of the stomach

  • III./1.1.4.: Peritoneal relations of the stomach

  • III./1.1.5.: Arterial blood supply of the stomach

  • III./1.1.6.: Venous drainage of the stomach

  • III./1.1.7.: The lymphatic drainage of the stomach

  • III./1.1.8.: Innervation of the stomach

  • III./1.1.9.: Interstitial cells of Cajal

  • III./1.1.10.: Internal relief of gastric mucosa

• III./1.2.: The wall structure of the stomach, Histology

  • III./1.2.1.: Tunica mucosa (mucous membrane)

  • III./1.2.2.: Tela submucosa

  • III./1.2.3.: Tunica muscularis propria

  • III./1.2.4.:Tela subserosa

  • III./1.2.5.: Tunica serosa

  • III./1.2.6.: Regional histological differences

    • III./1.2.6.1.: Cardia glands

    • III./1.2.6.2.: Fundus and corpus glands

      • III./1.2.6.2.1.: Mucous neck cells / mucus-secreting neck cells

      • III./1.2.6.2.2.: Undifferentiated cells

      • III./1.2.6.2.3.: Parietal (oxyntic) cells

      • III./1.2.6.2.4.: Chief cells (zymogenic cells)

      • III./1.2.6.2.5.: Enteroendocrine cells

    • III./1.2.6.3.: Pyloric glands

References

Szentágothai-Réthelyi: Funkcionális anatómia II. – Medicina, Budapest 2002.

Vígh: Szisztémás anatómia. Rendszeres orvosi bonctan. Alliter Bp. 2005.

Szél: Klinikai anatómia, 1999

Tömböl Teréz: Tájanatómia - Medicina 2001

Röhlich: Szövettan – Semmelweis Kiadó és Multimédia Stúdió, 2006

Moore: Clinically oriented anatomy - Lippincott Williams & Wilkins, 2009.

Gray’s Anatomy – Elsevier 2005.